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KMID : 0386319850180010057
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Korean Leprosy Bulletin
1985 Volume.18 No. 1 p.57 ~ p.61
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Hepatotoxity of Prothionamide in Multidrug-Therapy of Leprosy
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河龍馬/Yong-Ma Ha
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Abstract
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215 cases of new or relapsed leprosy cases were administered prothionamide in
combination with dapsone and refampicin on field wort, and following hepatotoxic effects
wee experienced.
1. 21.9% of total patients revealed hepatotoxic findings.
2. Higher proportion of hepatotoxicity is observed in female patients.
3. Toxicity seems paralell with dosage of prothionamide.
4. Incubation time was 108. 1 days.
5. all of affected cases were recovered spontaneously by cessation of the drug
administration, subjective symptoms subsided within shortterm period and laboratory
findings recovered in all cases within 4 months.
6. Thionamides are possible to administer for leprosy treatment in close observation
and available laboratory facilities.
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